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Ретинобластомоподобный белок 2
Идентификаторы
Символ	RBL2 ; P130; Rb2
Внешние ID	OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: RBL2 Gene
Генная онтология
Функция	• DNA binding; • protein binding;
Компонент клетки	• nucleus; • nucleoplasm; • transcription factor complex; • nucleolus; • cytoplasm; • extracellular vesicular exosome;
Биологический процесс	• mitotic cell cycle; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • chromatin modification; • regulation of lipid kinase activity; • regulation of cell cycle;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи
	Шаблон: просмотр • обсуждение • править

ПОИСК ПО САЙТУ | о проекте

Ретинобластомоподобный белок 2 — белок, который у человека, кодируется геном RBL2.^[1]^[2]

Взаимодействия

Ретинобластомоподобный белок 2, как было выявлено, взаимодействует с HDAC1,^[3]^[4] С-Raf,^[5] RBBP8,^[6]^[7] циклином Е1,^[8]^[9] прохибитином,^[10] циклинозависимой киназой 2,^[8]^[11] BRF1^[12] и BRCA1.^[13]

См. также

RBL1

Примечания

↑ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). “Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain”. Oncogene. 8 (9): 2561—6. PMID 8361765.
↑ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). “Genomic structure of the human retinoblastoma-related Rb2/p130 gene”. Proc Natl Acad Sci U S A. 93 (10): 4629—32. DOI:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.
↑ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). “The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (18): 10493—8. DOI:10.1073/pnas.95.18.10493. ISSN 0027-8424. PMC 27922. PMID 9724731.
↑ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). “Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo”. Cancer Res. UNITED STATES. 60 (16): 4531—7. ISSN 0008-5472. PMID 10969803.
↑ Wang, S; Ghosh R N; Chellappan S P (Dec 1998). “Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation”. Mol. Cell. Biol. UNITED STATES. 18 (12): 7487—98. ISSN 0270-7306. PMC 109329. PMID 9819434.
↑ Meloni, A R; Smith E J; Nevins J R (August 1999). “A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 96 (17): 9574—9. DOI:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734.
↑ Fusco, C; Reymond A; Zervos A S (August 1998). “Molecular cloning and characterization of a novel retinoblastoma-binding protein”. Genomics. UNITED STATES. 51 (3): 351—8. DOI:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205.
1 2 Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). “Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest”. Mol. Cell. Biol. UNITED STATES. 19 (2): 1460—9. ISSN 0270-7306. PMC 116074. PMID 9891079.
↑ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). “The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E”. Genes Dev. UNITED STATES. 7 (12A): 2366—77. DOI:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383.
↑ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). “Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function”. Oncogene. ENGLAND. 18 (23): 3501—10. DOI:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528.
↑ Lacy, S; Whyte P (May 1997). “Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes”. Oncogene. ENGLAND. 14 (20): 2395—406. DOI:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854.
↑ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). “RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130”. Mol. Cell. Biol. UNITED STATES. 19 (6): 4255—61. ISSN 0270-7306. PMC 104385. PMID 10330166.
↑ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). “Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding”. Oncogene. England. 20 (35): 4827—41. DOI:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194.

Литература

Soprano KJ, Purev E, Vuocolo S, Soprano DR (2006). “Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid”. Oncogene. 25 (38): 5315—25. DOI:10.1038/sj.onc.1209679. PMID 16936753.
De Falco G, Giordano A (2006). “pRb2/p130: a new candidate for retinoblastoma tumor formation”. Oncogene. 25 (38): 5333—40. DOI:10.1038/sj.onc.1209614. PMID 16936755.
Hijmans EM, Voorhoeve PM, Beijersbergen RL; et al. (1995). “E2F-5, a new E2F family member that interacts with p130 in vivo”. Mol. Cell. Biol. 15 (6): 3082—9. PMC 230539. PMID 7760804.

Sardet C, Vidal M, Cobrinik D; et al. (1995). “E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle”. Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403—7. DOI:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
Yeung RS, Bell DW, Testa JR; et al. (1993). “The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19”. Oncogene. 8 (12): 3465—8. PMID 8247552.
Li Y, Graham C, Lacy S; et al. (1994). “The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.”. Genes Dev. 7 (12A): 2366—77. DOI:10.1101/gad.7.12a.2366. PMID 8253383.
Hannon GJ, Demetrick D, Beach D (1994). “Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins”. Genes Dev. 7 (12A): 2378—91. DOI:10.1101/gad.7.12a.2378. PMID 8253384.
Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). “The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A”. Oncogene. 14 (22): 2721—8. DOI:10.1038/sj.onc.1201243. PMID 9178770.
Lacy S, Whyte P (1997). “Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes”. Oncogene. 14 (20): 2395—406. DOI:10.1038/sj.onc.1201085. PMID 9188854.
Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). “Rb interacts with TAF(II)250/TFIID through multiple domains”. Oncogene. 15 (4): 385—92. DOI:10.1038/sj.onc.1201204. PMID 9242374.
Sterner JM, Dew-Knight S, Musahl C; et al. (1998). “Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Mol. Cell. Biol. 18 (5): 2748—57. PMC 110654. PMID 9566894.
Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). “A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability”. Nat. Genet. 19 (4): 371—4. DOI:10.1038/1258. PMID 9697699.
Veal E, Eisenstein M, Tseng ZH, Gill G (1998). “A cellular repressor of E1A-stimulated genes that inhibits activation by E2F”. Mol. Cell. Biol. 18 (9): 5032—41. PMC 109088. PMID 9710587.
Fusco C, Reymond A, Zervos AS (1998). “Molecular cloning and characterization of a novel retinoblastoma-binding protein”. Genomics. 51 (3): 351—8. DOI:10.1006/geno.1998.5368. PMID 9721205.
Ferreira R, Magnaghi-Jaulin L, Robin P; et al. (1998). “The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase”. Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10493—8. DOI:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
Paramio JM, Laín S, Segrelles C; et al. (1998). “Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation”. Oncogene. 17 (8): 949—57. DOI:10.1038/sj.onc.1202031. PMID 9747874.
Wang S, Ghosh RN, Chellappan SP (1998). “Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation”. Mol. Cell. Biol. 18 (12): 7487—98. PMC 109329. PMID 9819434.
Yang R, Müller C, Huynh V; et al. (1999). “Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins”. Mol. Cell. Biol. 19 (3): 2400—7. PMC 84032. PMID 10022926.

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[pmid8361765-1] Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). “Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain”. Oncogene. 8 (9): 2561—6. PMID 8361765.

[pmid8643454-2] Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). “Genomic structure of the human retinoblastoma-related Rb2/p130 gene”. Proc Natl Acad Sci U S A. 93 (10): 4629—32. DOI:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.

[pmid9724731-3] Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). “The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 95 (18): 10493—8. DOI:10.1073/pnas.95.18.10493. ISSN 0027-8424. PMC 27922. PMID 9724731.

[pmid10969803-4] Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). “Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo”. Cancer Res. UNITED STATES. 60 (16): 4531—7. ISSN 0008-5472. PMID 10969803.

[pmid9819434-5] Wang, S; Ghosh R N; Chellappan S P (Dec 1998). “Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation”. Mol. Cell. Biol. UNITED STATES. 18 (12): 7487—98. ISSN 0270-7306. PMC 109329. PMID 9819434.

[pmid10449734-6] Meloni, A R; Smith E J; Nevins J R (August 1999). “A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 96 (17): 9574—9. DOI:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734.

[pmid9721205-7] Fusco, C; Reymond A; Zervos A S (August 1998). “Molecular cloning and characterization of a novel retinoblastoma-binding protein”. Genomics. UNITED STATES. 51 (3): 351—8. DOI:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205.

[pmid9891079-8] 1 2 Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). “Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest”. Mol. Cell. Biol. UNITED STATES. 19 (2): 1460—9. ISSN 0270-7306. PMC 116074. PMID 9891079.

[pmid8253383-9] Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). “The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E”. Genes Dev. UNITED STATES. 7 (12A): 2366—77. DOI:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383.

[pmid10376528-10] Wang, S; Nath N; Adlam M; Chellappan S (June 1999). “Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function”. Oncogene. ENGLAND. 18 (23): 3501—10. DOI:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528.

[pmid9188854-11] Lacy, S; Whyte P (May 1997). “Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes”. Oncogene. ENGLAND. 14 (20): 2395—406. DOI:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854.

[pmid10330166-12] Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). “RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130”. Mol. Cell. Biol. UNITED STATES. 19 (6): 4255—61. ISSN 0270-7306. PMC 104385. PMID 10330166.

[pmid11521194-13] Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). “Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding”. Oncogene. England. 20 (35): 4827—41. DOI:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194.