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Член 2 подсемейства ядерных рецепторов 2 группы F
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
	3CJW
Идентификаторы
Символ	NR2F2 ; ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
Внешние ID	OMIM: 107773 MGI: 1352452 HomoloGene: 7628 IUPHAR: NR2F2 GeneCards: NR2F2 Gene
Генная онтология
Функция	• retinoic acid binding; • sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • transcription corepressor activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • protein binding; • zinc ion binding; • protein homodimerization activity; • sequence-specific DNA binding;
Компонент клетки	• nucleus;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • neuron migration; • maternal placenta development; • negative regulation of endothelial cell proliferation; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • lipid metabolic process; • signal transduction; • skeletal muscle tissue development; • fertilization; • anterior/posterior pattern specification; • radial pattern formation; • negative regulation of endothelial cell migration; • intracellular receptor signaling pathway; • forebrain development; • response to estradiol; • steroid hormone mediated signaling pathway; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • blood vessel morphogenesis; • limb development; • placenta blood vessel development; • trophoblast giant cell differentiation; • regulation of transcription involved in lymphatic endothelial cell fate commitment;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи
	Шаблон: просмотр • обсуждение • править

ПОИСК ПО САЙТУ | о проекте

COUP-TFII ( транскрипционный фактор COUP 2 ), известный также как NR2F2 (подсемейство ядерных рецепторов 2, группы F, элемент 2) — белок, кодируемый у человека геном NR2F2^[1]^[2]. Аббревиатура COUP расшифровывается как chicken ovalbumin upstream promoter — расположенный выше по течению промотор овальбумина курицы.

Функция

COUP-TFII играет важную роль в регуляции развития ряда тканей и органов, включая сердце, кровеносные сосуды, мышцы и конечности^[3]^[4].

Глюкокортикоидные рецепторы стимулируют COUP-TFII опосредованную трансактивация генов, а сам COUP-TFII подавляет транскрипционную активность глюкокортикоидных рецепторов^[5]^[6]. COUP-TFII взаимодействует с GATA2, препятствуя дифференцировки адипоцитов^[7].

Взаимодействия

COUP-TFII.как было выявлено, взаимодействует с:

Примечания

↑ Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2 (неопр.).
↑ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). “Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes”. Genomics. 29 (1): 240—6. DOI:10.1006/geno.1995.1237. PMID 8530078.
↑ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). “The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development”. Genes Dev. 13 (8): 1037—49. DOI:10.1101/gad.13.8.1037. PMC 316637. PMID 10215630.
↑ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (December 2004). “The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development”. Mol. Cell. Biol. 24 (24): 10835—43. DOI:10.1128/MCB.24.24.10835-10843.2004. PMC 533959. PMID 15572686.
↑ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). “The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism”. Mol. Endocrinol. 18 (4): 820—33. DOI:10.1210/me.2003-0341. PMID 14739255.
↑ De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). “Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism”. Ann. N. Y. Acad. Sci. 1024: 72—85. DOI:10.1196/annals.1321.006. PMID 15265774.
↑ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). “The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis”. Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421—6. DOI:10.1073/pnas.0707082105. PMC 2268152. PMID 18250317.
↑ Smirnov DA, Hou S, Ricciardi RP (March 2000). “Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription”. Virology. 268 (2): 319—28. DOI:10.1006/viro.1999.0181. PMID 10704340.
↑ Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (November 1996). “A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor”. J. Biol. Chem. 271 (44): 27197—200. DOI:10.1074/jbc.271.44.27197. PMID 8910285.
↑ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). “Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2”. J. Biol. Chem. 274 (20): 14331—6. DOI:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
↑ Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM (May 2012). “Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells”. PLoS One. 7 (5). DOI:10.1371/journal.pone.0038278. PMC 3365040. PMID 22693611.

Литература

De Martino MU, Alesci S, Chrousos GP, Kino T (2004). “Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism”. Ann. N. Y. Acad. Sci. 1024: 72—85. DOI:10.1196/annals.1321.006. PMID 15265774.
Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE, Karathanasis SK (1992). “Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells”. Mol. Cell. Biol. 12 (4): 1708—18. PMC 369614. PMID 1312668.
Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ (1992). “The COUP-TFs compose a family of functionally related transcription factors”. Gene Expr. 1 (3): 207—16. PMID 1820218.
Ladias JA, Karathanasis SK (1991). “Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily”. Science. 251 (4993): 561—5. DOI:10.1126/science.1899293. PMID 1899293.
Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (1996). “A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor”. J. Biol. Chem. 271 (44): 27197—200. DOI:10.1074/jbc.271.44.27197. PMID 8910285.
Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). “Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1”. J. Biol. Chem. 272 (18): 12062—8. DOI:10.1074/jbc.272.18.12062. PMID 9115274.
Chu K, Zingg HH (1998). “The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter”. J. Mol. Endocrinol. 19 (2): 163—72. DOI:10.1677/jme.0.0190163. PMID 9343308.
Bailey P, Sartorelli V, Hamamori Y, Muscat GE (1999). “The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD”. Nucleic Acids Res. 26 (23): 5501—10. DOI:10.1093/nar/26.23.5501. PMC 147985. PMID 9826778.
Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (1999). “Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2”. J. Biol. Chem. 274 (20): 14331—6. DOI:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
Smirnov DA, Hou S, Ricciardi RP (2000). “Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription”. Virology. 268 (2): 319—28. DOI:10.1006/viro.1999.0181. PMID 10704340.
Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). “Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors”. J. Biol. Chem. 275 (14): 10315—22. DOI:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
Jordan EM, Worley T, Breen GA (2003). “Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1”. Biochemistry. 42 (9): 2656—63. DOI:10.1021/bi0268347. PMID 12614160.
Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H (2003). “Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle”. J. Clin. Endocrinol. Metab. 88 (7): 3415—20. DOI:10.1210/jc.2002-021723. PMID 12843196.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). “Functional Proteomics Mapping of a Human Signaling Pathway”. Genome Res. 14 (7): 1324—32. DOI:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Kurihara I, Shibata H, Kobayashi S, Suda N, Ikeda Y, Yokota K, Murai A, Saito I, Rainey WE, Saruta T (2005). “Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription”. J. Biol. Chem. 280 (8): 6721—30. DOI:10.1074/jbc.M411820200. PMID 15611122.
Shibata H, Kobayashi S, Kurihara I, Suda N, Yokota K, Murai A, Ikeda Y, Saito I, Rainey WE, Saruta T (2005). “COUP-TF and transcriptional co-regulators in adrenal steroidogenesis”. Endocr. Res. 30 (4): 795—801. DOI:10.1081/ERC-200044042. PMID 15666827.

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[entrez-1] Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2 (неопр.).

[pmid8530078-2] Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). “Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes”. Genomics. 29 (1): 240—6. DOI:10.1006/geno.1995.1237. PMID 8530078.

[pmid10215630-3] Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). “The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development”. Genes Dev. 13 (8): 1037—49. DOI:10.1101/gad.13.8.1037. PMC 316637. PMID 10215630.

[pmid15572686-4] Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (December 2004). “The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development”. Mol. Cell. Biol. 24 (24): 10835—43. DOI:10.1128/MCB.24.24.10835-10843.2004. PMC 533959. PMID 15572686.

[pmid14739255-5] De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). “The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism”. Mol. Endocrinol. 18 (4): 820—33. DOI:10.1210/me.2003-0341. PMID 14739255.

[pmid15265774-6] De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). “Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism”. Ann. N. Y. Acad. Sci. 1024: 72—85. DOI:10.1196/annals.1321.006. PMID 15265774.

[pmid18250317-7] Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). “The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis”. Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421—6. DOI:10.1073/pnas.0707082105. PMC 2268152. PMID 18250317.

[pmid10704340-8] Smirnov DA, Hou S, Ricciardi RP (March 2000). “Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription”. Virology. 268 (2): 319—28. DOI:10.1006/viro.1999.0181. PMID 10704340.

[pmid8910285-9] Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (November 1996). “A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor”. J. Biol. Chem. 271 (44): 27197—200. DOI:10.1074/jbc.271.44.27197. PMID 8910285.

[pmid10318855-10] Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). “Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2”. J. Biol. Chem. 274 (20): 14331—6. DOI:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.

[pmid22693611-11] Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM (May 2012). “Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells”. PLoS One. 7 (5). DOI:10.1371/journal.pone.0038278. PMC 3365040. PMID 22693611.