WikiSort.ru - Не сортированное

HES1
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
	2MH3
Идентификаторы
Символы	HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1
Внешние IDs	MGI: 104853 HomoloGene: 38067 GeneCards: 3280
Генная онтология
Функции	• protein dimerization activity; • transcription factor activity, sequence-specific DNA binding; • histone deacetylase binding; • transcription factor binding; • связывание с белками плазмы; • sequence-specific DNA binding; • chaperone binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • N-box binding; • гомодимеризация белка; • ДНК-связывающий; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • transcription corepressor activity; • E-box binding; • sequence-specific double-stranded DNA binding; • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;
Компонент клетки	• цитоплазма; • внутриклеточный; • клеточное ядро; • нуклеоплазма;
Биологический процесс	• pattern specification process; • auditory receptor cell fate determination; • midbrain-hindbrain boundary morphogenesis; • inner ear receptor stereocilium organization; • negative regulation of neuron differentiation; • metanephric nephron tubule morphogenesis; • cell morphogenesis involved in neuron differentiation; • regulation of transcription from RNA polymerase II promoter; • lateral inhibition; • cardiac neural crest cell development involved in outflow tract morphogenesis; • negative regulation of stem cell differentiation; • auditory receptor cell differentiation; • negative regulation of pro-B cell differentiation; • negative regulation of inner ear receptor cell differentiation; • regulation of neurogenesis; • positive regulation of Notch signaling pathway; • cochlea development; • cell fate commitment; • ДНК-зависимая регуляция транскрипции; • развитие лёгких; • negative regulation of auditory receptor cell differentiation; • negative regulation of cell differentiation; • labyrinthine layer blood vessel development; • in utero embryonic development; • cell maturation; • adenohypophysis development; • regulation of timing of neuron differentiation; • regulation of fat cell differentiation; • транскрипция, ДНК-зависимая; • ДНК-зависимая позитивная регуляция транскрипции; • telencephalon development; • positive regulation of T cell proliferation; • neural tube development; • pancreas development; • hindbrain morphogenesis; • smoothened signaling pathway; • negative regulation of stomach neuroendocrine cell differentiation; • ureteric bud morphogenesis; • regulation of auditory receptor cell differentiation; • oculomotor nerve development; • regulation of timing of cell differentiation; • nervous system development; • Агрегация клеток; • positive regulation of BMP signaling pathway; • midbrain development; • establishment of epithelial cell polarity; • pituitary gland development; • comma-shaped body morphogenesis; • somatic stem cell population maintenance; • trochlear nerve development; • aorta morphogenesis; • negative regulation of forebrain neuron differentiation; • negative regulation of pancreatic A cell differentiation; • regulation of secondary heart field cardioblast proliferation; • common bile duct development; • renal interstitial fibroblast development; • forebrain radial glial cell differentiation; • S-shaped body morphogenesis; • glomerulus vasculature development; • liver development; • regulation of epithelial cell proliferation; • миграция клеток; • положительная регуляция транскрипции РНК полимеразой II промотор; • ventricular septum morphogenesis; • negative regulation of oligodendrocyte differentiation; • ascending aorta morphogenesis; • outflow tract morphogenesis; • positive regulation of astrocyte differentiation; • ventricular septum development; • vascular smooth muscle cell development; • embryonic heart tube morphogenesis; • positive regulation of JAK-STAT cascade; • Notch signaling pathway; • positive regulation of mitotic cell cycle, embryonic; • negative regulation of transcription, DNA-templated; • thymus development; • positive regulation of DNA binding; • negative regulation of glial cell proliferation; • neuronal stem cell population maintenance; • позитивная регуляция пролиферации клеток; • negative regulation of transcription from RNA polymerase II promoter; • artery morphogenesis; • pharyngeal arch artery morphogenesis; • positive regulation of tyrosine phosphorylation of STAT protein; • macromolecular complex assembly; • regulation of JAK-STAT cascade; • somitogenesis; • Дифференцировка клеток;
	Источники:Amigo / QuickGO
Профиль экспрессии РНК
	; ;
	Больше информации
Ортологи
	3280
	15205
	ENSG00000114315
	ENSMUSG00000022528
	Q14469
	P35428
	NM_005524
	NM_008235
	NP_005515
	NP_032261
	Викиданные
Просмотр/Править (Человек)	Просмотр/Править (Мышь)

ПОИСК ПО САЙТУ | о проекте

Структура

Взаимодействия

HES1 и стволовые клетки

Развитие нервной системы

Взаимодействие с белками сигнального пути Notch

Развитие пищеварительной системы

Примечания

Список литературы

Takebayashi K, Sasai Y, Sakai Y, Watanabe T, Nakanishi S, Kageyama R (1994). “Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements”. J. Biol. Chem. 269 (7): 5150—6. PMID 7906273.
Grbavec D, Stifani S (1996). “Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif”. Biochem. Biophys. Res. Commun. 223 (3): 701—5. DOI:10.1006/bbrc.1996.0959. PMID 8687460.
Ström A, Castella P, Rockwood J, Wagner J, Caudy M (1998). “Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation”. Genes Dev. 11 (23): 3168—81. DOI:10.1101/gad.11.23.3168. PMC 316755. PMID 9389649.
Votruba M, Payne A, Moore AT, Bhattacharya SS (1998). “Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY”. Mamm. Genome. 9 (10): 784—7. DOI:10.1007/s003359900867. PMID 9745030.
Bae S, Bessho Y, Hojo M, Kageyama R (2000). “The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation”. Development. 127 (13): 2933—43. PMID 10851137.
Yao J, Lai E, Stifani S (2001). “The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription”. Mol. Cell. Biol. 21 (6): 1962—72. DOI:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932.
Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y (2001). “HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling”. Mol. Cell. Biol. 21 (17): 6080—9. DOI:10.1128/MCB.21.17.6080-6089.2001. PMC 87325. PMID 11486045.
Dintilhac A, Bernués J (2002). “HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences”. J. Biol. Chem. 277 (9): 7021—8. DOI:10.1074/jbc.M108417200. PMID 11748221.
Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). “Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation”. J. Biol. Chem. 277 (11): 9118—26. DOI:10.1074/jbc.M107713200. PMID 11756408.
Kunisato A, Chiba S, Nakagami-Yamaguchi E, Kumano K, Saito T, Masuda S, Yamaguchi T, Osawa M, Kageyama R, Nakauchi H, Nishikawa M, Hirai H (2003). “HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo”. Blood. 101 (5): 1777—83. DOI:10.1182/blood-2002-07-2051. PMID 12406868.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takata T, Ishikawa F (2003). “Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression”. Biochem. Biophys. Res. Commun. 301 (1): 250—7. DOI:10.1016/S0006-291X(02)03020-6. PMID 12535671.
Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003). “Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms”. Mol. Cell. Biol. 23 (19): 6922—35. DOI:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610.
Thomsen JS, Kietz S, Ström A, Gustafsson JA (2004). “HES-1, a novel target gene for the aryl hydrocarbon receptor”. Mol. Pharmacol. 65 (1): 165—71. DOI:10.1124/mol.65.1.165. PMID 14722248.
Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (2004). “Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling”. Nat. Cell Biol. 6 (6): 547—54. DOI:10.1038/ncb1138. PMID 15156153.
Persson P, Stockhausen MT, Påhlman S, Axelson H (2005). “Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells”. Int. J. Oncol. 25 (5): 1213—21. DOI:10.3892/ijo.25.5.1213. PMID 15492808.
Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L, Bigas A (2004). “Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression”. Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16537—42. DOI:10.1073/pnas.0404429101. PMC 534509. PMID 15536134.
Fryer CJ, White JB, Jones KA (2005). “Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover”. Mol. Cell. 16 (4): 509—20. DOI:10.1016/j.molcel.2004.10.014. PMID 15546612.

Ссылки

MeSH HES1+protein,+human

Эта статья содержит текст из Национальной библиотеки медицины США, который находится в общественом достоянии.

Данная страница на сайте WikiSort.ru содержит текст со страницы сайта "Википедия".

Если Вы хотите её отредактировать, то можете сделать это на странице редактирования в Википедии.

Если сделанные Вами правки не будут кем-нибудь удалены, то через несколько дней они появятся на сайте WikiSort.ru .

Текст в блоке "Читать" взят с сайта "Википедия" и доступен по лицензии Creative Commons Attribution-ShareAlike; в отдельных случаях могут действовать дополнительные условия.

Другой контент может иметь иную лицензию. Перед использованием материалов сайта WikiSort.ru внимательно изучите правила лицензирования конкретных элементов наполнения сайта.

2019-2025
WikiSort.ru - проект по пересортировке и дополнению контента Википедии