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ASCL1
Идентификаторы
Символы	ASCL1, ASH1, HASH1, MASH1, bHLHa46, achaete-scute family bHLH transcription factor 1
Внешние IDs	MGI: 96919 HomoloGene: 31234 GeneCards: 429
Генная онтология
Функции	• ДНК-связывающий; • sequence-specific DNA binding; • protein dimerization activity; • transcription factor activity, transcription factor binding; • гомодимеризация белка; • transcription factor activity, sequence-specific DNA binding; • chromatin binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • bHLH transcription factor binding; • E-box binding; • связывание с белками плазмы; • double-stranded DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • transcription factor binding; • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;
Компонент клетки	• neuronal cell body; • клеточное ядро; • RNA polymerase II transcription factor complex;
Биологический процесс	• Notch signaling pathway; • commitment of neuronal cell to specific neuron type in forebrain; • sympathetic ganglion development; • pattern specification process; • noradrenergic neuron development; • cerebral cortex GABAergic interneuron differentiation; • Нейрогенез; • Дифференцировка клеток; • stomach neuroendocrine cell differentiation; • ДНК-зависимая регуляция транскрипции; • negative regulation of neuron differentiation; • response to retinoic acid; • spinal cord association neuron differentiation; • sympathetic nervous system development; • neuroblast fate determination; • regulation of transcription from RNA polymerase II promoter; • spinal cord oligodendrocyte cell fate specification; • musculoskeletal movement, spinal reflex action; • негативная регуляция апоптоза; • neuron migration; • glial cell differentiation; • negative regulation of transcription from RNA polymerase II promoter; • cell maturation; • cellular response to magnetism; • oligodendrocyte differentiation; • olfactory pit development; • транскрипция, ДНК-зависимая; • lung neuroendocrine cell differentiation; • nervous system development; • generation of neurons; • response to lithium ion; • multicellular organism development; • positive regulation of neural precursor cell proliferation; • adrenal chromaffin cell differentiation; • positive regulation of neurogenesis; • positive regulation of neuron apoptotic process; • ventral spinal cord interneuron fate commitment; • central nervous system neuron development; • positive regulation of cell cycle; • response to epidermal growth factor; • regulation of cell proliferation; • vestibular nucleus development; • positive regulation of neuron differentiation; • regulation of mitotic cell cycle; • forebrain neuron differentiation; • cerebral cortex development; • regulation of gene expression; • neuroblast proliferation; • subpallium neuron fate commitment; • regulation of timing of subpallium neuron differentiation; • oligodendrocyte development; • lung epithelial cell differentiation; • carotid body glomus cell differentiation; • response to folic acid; • spinal cord oligodendrocyte cell differentiation; • regulation of epithelial cell differentiation; • negative regulation of transcription, DNA-templated; • noradrenergic neuron fate commitment; • regulation of Notch signaling pathway; • regulation of neurogenesis; • positive regulation of Notch signaling pathway; • положительная регуляция транскрипции РНК полимеразой II промотор; • oligodendrocyte cell fate commitment; • neuron differentiation; • neuron fate commitment; • neuron fate specification; • neuron development; • развитие сердца; • sensory organ development;
	Источники:Amigo / QuickGO
Профиль экспрессии РНК
	; ; ; ;
	Больше информации
Ортологи
	429
	17172
	ENSG00000139352
	ENSMUSG00000020052
	P50553
	Q02067
	NM_004316
	NM_008553
	NP_004307
	NP_032579
	Викиданные
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ПОИСК ПО САЙТУ | о проекте

Функция

Роль в дифференцировке нейронов

Развитие вегетативной нервной системы

Взаимодействия

Примечания

Список литературы

Chen H, Kunnimalaiyaan M, Van Gompel JJ (Jun 2005). “Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1”. Thyroid. 15 (6): 511—21. DOI:10.1089/thy.2005.15.511. PMID 16029117.
Renault B, Lieman J, Ward D, Krauter K, Kucherlapati R (Nov 1995). “Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23”. Genomics. 30 (1): 81—3. DOI:10.1006/geno.1995.0012. PMID 8595908.
Mao Z, Nadal-Ginard B (Jun 1996). “Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A”. The Journal of Biological Chemistry. 271 (24): 14371—5. DOI:10.1074/jbc.271.24.14371. PMID 8662987.
Borges M, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M, Baylin SB, Ball DW (Apr 1997). “An achaete-scute homologue essential for neuroendocrine differentiation in the lung”. Nature. 386 (6627): 852—5. DOI:10.1038/386852a0. PMID 9126746.
Chen H, Biel MA, Borges MW, Thiagalingam A, Nelkin BD, Baylin SB, Ball DW (Jun 1997). “Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions”. Cell Growth & Differentiation. 8 (6): 677—86. PMID 9186001.
Lo L, Sommer L, Anderson DJ (Jun 1997). “MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells”. Current Biology. 7 (6): 440—50. DOI:10.1016/S0960-9822(06)00191-6. PMID 9197246.
Rozovskaia T, Rozenblatt-Rosen O, Sedkov Y, Burakov D, Yano T, Nakamura T, Petruck S, Ben-Simchon L, Croce CM, Mazo A, Canaani E (Jan 2000). “Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins”. Oncogene. 19 (3): 351—7. DOI:10.1038/sj.onc.1203307. PMID 10656681.
Persson P, Jögi A, Grynfeld A, Påhlman S, Axelson H (Jul 2000). “HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex”. Biochemical and Biophysical Research Communications. 274 (1): 22—31. DOI:10.1006/bbrc.2000.3090. PMID 10903890.
Maxon ME, Herskowitz I (Feb 2001). “Ash1p is a site-specific DNA-binding protein that actively represses transcription”. Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1495—500. DOI:10.1073/pnas.98.4.1495. PMC 29285. PMID 11171979.
Long RM, Gu W, Meng X, Gonsalvez G, Singer RH, Chartrand P (Apr 2001). “An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast”. The Journal of Cell Biology. 153 (2): 307—18. DOI:10.1083/jcb.153.2.307. PMC 2169461. PMID 11309412.
Parras CM, Schuurmans C, Scardigli R, Kim J, Anderson DJ, Guillemot F (Feb 2002). “Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity”. Genes & Development. 16 (3): 324—38. DOI:10.1101/gad.940902. PMC 155336. PMID 11825874.
Sriuranpong V, Borges MW, Strock CL, Nakakura EK, Watkins DN, Blaumueller CM, Nelkin BD, Ball DW (May 2002). “Notch signaling induces rapid degradation of achaete-scute homolog 1”. Molecular and Cellular Biology. 22 (9): 3129—39. DOI:10.1128/MCB.22.9.3129-3139.2002. PMC 133746. PMID 11940670.
Westerman BA, Neijenhuis S, Poutsma A, Steenbergen RD, Breuer RH, Egging M, van Wijk IJ, Oudejans CB (Apr 2002). “Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features”. Clinical Cancer Research. 8 (4): 1082—6. PMID 11948117.
Letinic K, Zoncu R, Rakic P (Jun 2002). “Origin of GABAergic neurons in the human neocortex”. Nature. 417 (6889): 645—9. DOI:10.1038/nature00779. PMID 12050665.
de Pontual L, Népote V, Attié-Bitach T, Al Halabiah H, Trang H, Elghouzzi V, Levacher B, Benihoud K, Augé J, Faure C, Laudier B, Vekemans M, Munnich A, Perricaudet M, Guillemot F, Gaultier C, Lyonnet S, Simonneau M, Amiel J (Dec 2003). “Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse)”. Human Molecular Genetics. 12 (23): 3173—80. DOI:10.1093/hmg/ddg339. PMID 14532329.
Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H (Dec 2003). “The role of human achaete-scute homolog-1 in medullary thyroid cancer cells”. Surgery. 134 (6): 866—71, discussion 871–3. DOI:10.1016/S0039. PMID 14668716.
Ferretti E, Di Stefano D, Zazzeroni F, Gallo R, Fratticci A, Carfagnini R, Angiulli S, Santoro A, Minniti G, Tamburrano G, Alesse E, Cantore G, Gulino A, Jaffrain-Rea ML (Oct 2003). “Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1”. Journal of Endocrinological Investigation. 26 (10): 957—65. DOI:10.1007/bf03348192. PMID 14759067.
Mhawech P, Berczy M, Assaly M, Herrmann F, Bouzourene H, Allal AS, Dulguerov P, Schwaller J (Jul 2004). “Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tract”. American Journal of Clinical Pathology. 122 (1): 100—5. DOI:10.1309/QD0K-9Q1J-BH6B-5GQQ. PMID 15272537.

Ссылки

MeSH ASCL1+protein,+human

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Подавляет	Notch